P203 Volatile organic compounds in adults with cystic fibrosis by real-time proton-transfer reaction mass spectrometry

To study of exhaled volatile organic compounds (eVOCs) as diagnostic markers, assessment the progression respiratory diseases is becoming more widespread. Due to its noninvasive character, detection eVOCs with a using real-time proton mass spectrometry air (PTR-MS) in patients cystic fibrosis (CF) seems be particularly attractive. assess changes qualitative and quantitative composition CF group healthy volunteers PTR-MS air. Single forced expiratory samples 50 adult (25 M/ 25 F, mean age 26 ± 6 yrs) 52 (20 32 27 comparable for sex were analyzed proton-transfer reaction spectrometer (Compact PTR-MS, Ionicon, Austria). profiles listed ions at various mass-to-charge ratios (m/z). When comparing volunteers, significant differences found level representation 29 (p < 0.001) associated fibrosis. Data assessed by support-vector machine classifier (SVM). The model normalization evaluation developed on basis experimental data obtained makes it possible differentiate from normal AUC = 0.987. provides breath fingerprinting fibrosis, can used fast, low-cost non-invasive diagnosis